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目的评价细胞角蛋白21-1(CYFRA21-1)与转移生长因子-β1(TGF-β1)联合检测诊断良恶性腹水的意义。方法选取82例腹水患者,采用酶联免疫吸附试验检测其腹水中CYFRA21-1与TGF-β1水平。结果肝癌组患者腹水中CYFRA21-1明显高于结核性腹膜炎和弥漫性腹膜炎患者,差异有统计学意义(P<0.05);肝癌组患者腹水中TGF-β1明显高于结核性腹膜炎患者,差异有统计学意义(P<0.05)。结论 CYFRA21-1与TGF-β1联合检测对诊断癌性腹水和结核性腹膜炎具有实际临床意义。
Objective To evaluate the value of combined detection of cytokeratin 21-1 (CYFRA21-1) and transforming growth factor-β1 (TGF-β1) in the diagnosis of benign and malignant ascites. Methods Eighty-two ascites patients were selected. The levels of CYFRA21-1 and TGF-β1 in ascites were detected by enzyme-linked immunosorbent assay (ELISA). Results The level of CYFRA21-1 in ascites of patients with hepatocellular carcinoma was significantly higher than that of patients with tuberculous peritonitis and diffuse peritonitis (P <0.05). The level of TGF-β1 in ascites of patients with hepatocellular carcinoma was significantly higher than that of patients with tuberculous peritonitis Statistical significance (P <0.05). Conclusion Combined detection of CYFRA21-1 and TGF-β1 has practical clinical significance in the diagnosis of cancerous ascites and tuberculous peritonitis.