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目的以葛根素为模型药物制备口腔崩解片。方法该研制把崩解时间及沉降容积比为指标,单因素法筛选片剂的处方组成及工艺,并优化制备工艺。结果葛根素口腔崩解片的辅料为甘露醇、明胶、阿司帕坦与薄荷香精,经过冷冻干燥方法制备,口感良好,4s的崩解时间,在4min内体外溶出度达96.46%。结论葛根素口腔崩解片可迅速崩解于口腔内,制备工艺可行。
Objective To prepare orally disintegrating tablets with puerarin as a model drug. Methods The disintegration time and sedimentation volume ratio of the research as an indicator, single-factor screening of prescription formulations and processes, and optimize the preparation process. Results The puerarin orally disintegrating tablets were mannitol, gelatin, aspartame and mint flavor, which were prepared by freeze-drying. The mouthfeel was good and the disintegration time was 4s. The dissolution rate in vitro reached 96.46% in 4 minutes. Conclusion Puerarin orally disintegrating tablets can be quickly disintegrated in the oral cavity, the preparation process is feasible.