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肺癌是全球新发病例和死亡病例均居首位的恶性肿瘤,影响患者预后的主要因素是出现局部复发及远处转移。新近研究表明,上皮间质转化(EMT)在肿瘤演进中是一个重要的决定性过程,与肿瘤细胞侵袭、转移乃至“干性”等密切相关。1 EMT概念EMT是上皮细胞失去上皮特性获得间质细胞表型的一种生物现象。EMT发生后,细胞间连接蛋白及上皮特异性蛋白表达下降,如E-钙黏蛋白(E-cad)、β-连锁蛋白等;同时伴随间充质细胞特异性蛋白表达增高,如波形蛋白(vimentin)、N-钙
Lung cancer is the world’s new and fatal cases ranked first in malignant tumors, the prognosis of patients with the main factor is the emergence of local recurrence and distant metastasis. Recent studies have shown that epithelial-mesenchymal transition (EMT) is an important determinant of tumor progression and is closely related to tumor cell invasion, metastasis and even “dryness”. 1 EMT Concept EMT is a biological phenomenon that epithelial cells lose their epithelial properties to obtain stromal cell phenotypes. After EMT, the expression of intercellular connexin and epithelial specific protein decreased, such as E-cadherin, β-catenin and so on; accompanied by increased expression of mesenchymal cell specific protein, such as vimentin vimentin), N-calcium