鸦片剂在镇痛和调解神经内分泌系统对外界刺激的反应方面的作用是众所周知的。本文研究了原发性非器质性头痛即普通偏头痛(CM);有阵发性头痛的偏头痛(MIH);丛集性头痛(CH)时血清和脑脊液中B-脂肪酸动员激素(B-LPH),B-内啡肽(B-EP)和ACTH的变化。并与器质性疾病的症状性头痛即慢性创伤后头痛(CPTH)、脑血管缺血性头痛(ICVH)进行了比较,提出以这些物质在脑脊液中的水平作为中枢神经系统鸦片活性的一项 The role of opiates in the analgesic and mediating responses of the neuroendocrine system to external stimuli is well known. This study investigated the effects of primary non-organic headache, general migraine (CM), paroxysmal headache migraine (MIH), cluster headache (CH) serum and CSF B-fatty acid mobilization hormone (B- LPH), B-endorphin (B-EP) and ACTH. And compared with the symptomatic headaches of organic diseases, namely, chronic post-traumatic headache (CPTH) and cerebrovascular ischemic headache (ICVH), and proposed that the levels of these substances in cerebrospinal fluid be used as a central opioid