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目的探讨不同类型足月儿血清抵抗素及胰岛素水平与胎儿宫内生长发育的关系。方法收集2010年10月至2011年5月在山西省儿童医院新生儿科住院、无严重疾病的足月新生儿(日龄<24h):分为小于胎龄儿(SGA)组、适于胎龄儿(AGA)组和大于胎龄儿(LGA)组,用酶联免疫吸附测定法检测其生后24h内血清抵抗素及胰岛素水平,并分析血清抵抗素和胰岛素之间的关系。结果 (1)血清抵抗素水平(ng/ml)随体重增加而下降,LGA组低于SGA组[(6.6±0.3)比(7.9±0.5),P<0.05]。(2)胰岛素水平(mIU/ml)随体重增加而上升,LGA组高于AGA组和SGA组[(75.9±5.0)比(58.8±5.6)、(43.3±3.6),P分别<0.05和0.01],AGA组高于SGA组(P<0.05)。(3)各组血清抵抗素和胰岛素水平均无明显相关性(SGA组:r=-0.229,AGA组:r=-0.405,LGA组:r=-0.241,P均>0.05)。结论新生儿血清抵抗素及胰岛素均在一定程度上反映了胎儿宫内生长发育的情况,但二者调节胎儿宫内生长的相互关系尚不完全明确。
Objective To investigate the relationship between serum resistin and insulin levels and fetal growth in different types of term infants. Methods The full-term newborns (day <24 h) who were hospitalized in Department of Neonatology, Children’s Hospital of Shanxi Province from October 2010 to May 2011 were divided into three groups: small-gestational age (SGA) (AGA) group and LGA group. The levels of serum resistin and insulin within 24h after birth were measured by enzyme-linked immunosorbent assay (ELISA), and the relationship between serum resistin and insulin was analyzed. Results (1) Serum resistin level (ng / ml) decreased with body weight gain. The LGA group was lower than that of SGA group (6.6 ± 0.3 vs 7.9 ± 0.5, P <0.05). (2) Insulin levels (mIU / ml) increased with weight gain. LGA group was higher than AGA group and SGA group [(75.9 ± 5.0) vs (58.8 ± 5.6) and (43.3 ± 3.6) ], AGA group was higher than SGA group (P <0.05). (3) There was no significant correlation between serum resistin and insulin levels in each group (SGA group: r = -0.229, AGA group: r = -0.405, LGA group: r = -0.241, P all> 0.05). Conclusion Neonatal serum resistin and insulin both reflect the intrauterine growth and development to a certain extent, but the relationship between the two in regulating intrauterine growth is not completely understood.