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哮喘是气道慢性炎症性疾病,通常出现广泛多变的可逆性气流受限,并引起反复发作性的喘息、气急、胸闷或咳嗽等症状。糖皮质激素作为治疗哮喘最有效的抗炎药物,是治疗哮喘的基石。但是哮喘患者对糖皮质激素的敏感性却呈现很大的差异,有的甚至出现激素抵抗。越来越多的研究发现,维生素D可以通过增强糖皮质激素抗炎效应或逆转激素抵抗作用来治疗哮喘,本文就维生素D与糖皮质激素的协同作用的相关研究及其机制等方面进行综述。
Asthma is a chronic inflammatory disease of the airways and usually has a fluctuating and reversible airflow limitation and causes recurrent episodes of wheezing, shortness of breath, chest tightness or coughing. Glucocorticoids as the most effective anti-inflammatory drugs for the treatment of asthma, is the cornerstone of the treatment of asthma. However, the sensitivity of asthma patients to glucocorticoid has shown a great difference, and some even appear hormone resistance. More and more studies have found that vitamin D can enhance the anti-inflammatory effects of glucocorticoids or reverse the effects of hormones to treat asthma. In this paper, the synergistic effects of vitamin D and glucocorticoids are reviewed.