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食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)是我国常见食管癌(esophageal cancer,EC)的主要亚型。虽然ESCC从分子遗传学角度已被广泛研究,但其发病分子机制还没有完全阐明。micro RNAs(mi RNAs)是一类小的内源性非蛋白编码RNAs,在生理、病理过程中发挥着重要作用,包括细胞分化、凋亡、增殖和代谢。mi RNAs通过致癌基因、抑癌基因在ESCC的发病机制中扮演着重要角色。近年来研究表明,许多mi RNAs在ESCC组织中的表达存在明显的差异,了解mi RNAs及其靶基因在ESCC发生发展中的作用,可能为早期检测、诊断、治疗和预后提供策略。
Esophageal squamous cell carcinoma (ESCC) is a common subtype of esophageal cancer (EC) in China. Although ESCC has been extensively studied from the perspective of molecular genetics, its molecular mechanism of pathogenesis has not yet been fully elucidated. Micro RNAs (mi RNAs) are small, endogenous, non-protein-encoding RNAs that play important roles in both physiological and pathological processes, including cell differentiation, apoptosis, proliferation and metabolism. miRNAs play an important role in the pathogenesis of ESCC through oncogenes and tumor suppressor genes. In recent years, studies have shown that there are significant differences in the expression of many mi RNAs in ESCC tissues. Understanding the role of mi RNAs and their target genes in the development of ESCC may provide strategies for early detection, diagnosis, treatment and prognosis.