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目的检测苏中圩田地区褐家鼠对第一代抗凝血灭鼠剂杀鼠灵的抗药性。方法按照全国鼠类抗药性监测协作组制定的方法,进行实验室无选择性摄食试验。结果 16只褐家鼠在观察期内全部死亡,平均死亡天数为6.31 d,平均致死剂量为27.99 mg/kg,试鼠性别间在致死剂量与死亡时间上均无显著性差异(P>0.05)。结论第一代抗凝血灭鼠剂杀鼠灵可继续用于毒杀褐家鼠,同时应加强敏感性与抗药性监测。
Objective To detect the resistance of Rattus norvegicus to the first-generation anticoagulant rodenticide warfarin in the polder areas of central Jiangsu Province. Methods According to the method developed by the cooperative monitoring group of the national drug resistance monitoring in mice, the experiment of non-selective feeding in laboratory was conducted. Results All of the 16 Rattus norvegicus patients died during the observation period with an average of 6.31 days of death and an average lethal dose of 27.99 mg / kg. There was no significant difference in the lethal doses and the time of death between the sexes (P> 0.05) . Conclusion The first-generation anticoagulant rodenticide warfarin can continue to be used to poison Rattus norvegicus, and sensitivity and drug resistance monitoring should be strengthened.