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目的探讨维生素D受体(VDR)基因BsmI位点多态性与小儿反复呼吸道感染(RRTI)的相关性,寻找RRTI的易感基因。方法应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术,检测2004年3月至2006年2月长春市儿童医院97例RRTI患儿和同期于该院体检的100名健康对照组儿童血浆VDR基因BsmI位点基因型。结果RRTI组BB、Bb基因型出现频率与健康对照组相比,有增高的趋势(χ2=14.97,P<0.01)。结论维生素D受体基因多态性与小儿反复呼吸道感染的发病具有相关性。
Objective To investigate the association between the BsmI polymorphism of vitamin D receptor (VDR) gene and children with recurrent respiratory tract infection (RRTI) and to find the RRTI susceptibility genes. Methods PCR-RFLP was used to detect 97 patients with RRTI from Changchun Children’s Hospital from March 2004 to February 2006 and 100 from the same period The healthy control group children with plasma VDR gene BsmI locus genotypes. Results The frequencies of BB and Bb genotypes in RRTI group were higher than those in healthy controls (χ2 = 14.97, P <0.01). Conclusion The polymorphism of vitamin D receptor gene is associated with the incidence of recurrent respiratory tract infections in children.