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尼可地尔(Nicorandil)具有迅速扩张冠脉血管,治疗心绞痛,其长效和速效作用均优于硝酸甘油,并能减慢心率,降低心室壁张力及缓慢而持久的降压作用。目前已作为新型抗心绞痛药物应用于临床。一、对冠脉血管的扩张作用及作用机理尼可地尔经口服或静脉给药,实验性动物的冠状血管迅速扩张。这种扩张作用无论对麻醉动物或有意识动物均为有效。麻醉狗静注本品50μg/kg,冠脉血流量较给药前平均增加52％。静注100μg/kg,平均增加78％,注射250μg/lg或更大剂量时,冠脉血流量非
Nicorandil has the ability to rapidly dilate coronary arteries and treat angina pectoris. Its long-acting and quick-acting effects are superior to nitroglycerin, and can slow heart rate, reduce ventricular wall tension and slow and sustained antihypertensive effect. Has now been used as a new anti-anginal drugs in clinical. First, the expansion of the role of coronary vessels and mechanism of action Nicorandil by oral or intravenous administration, rapid expansion of experimental animals coronary blood vessels. This expansion is effective in anesthetized animals or conscious animals. Anesthetic dogs intravenous injection of this product 50μg / kg, coronary blood flow increased by an average of 52% before administration. Intravenous injection of 100μg / kg, with an average increase of 78%, injection of 250μg / lg or greater dose, coronary blood flow is not