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目的 研究骨肉瘤p5 3、PTEN表达与其 3年存活之间的关系。方法 运用免疫组化方法检测 5 3例骨肉瘤病理标本p5 3、PTEN蛋白表达情况 ,并与术后 3年随访结果对照分析。结果 运用 χ2 检验进行统计学分析发现 ,p5 3阴性表达时 ,PTEN表达的 2种形式与随访结果有显著性差异 (χ2 =3 5 .95 ,Ρ <0 .0 0 5 ) ,p5 3阳性表达时 ,PTEN表达的 2种形式与随访结果无统计学差异 (χ2 =0 .175 ,Ρ =0 .997)。p5 3及PTEN的表达与随访结果的两因素logistic回归分析 ,只有PTEN表达进入回归模型 ,p5 3没有进入模型 ,PTEN表达与随访结果呈正相关关系。结论 p5 3、PTEN骨肉瘤中的表达与其对预后判定的作用上PTEN较p5 3作用更大
Objective To study the relationship between the expression of p5 3 and PTEN in osteosarcoma and its 3-year survival. Methods Immunohistochemistry was used to detect the expression of p35, PTEN protein in 53 cases of osteosarcoma. The results were compared with the results of 3 years follow-up. Results Statistical analysis using χ2 test showed that there was a significant difference between the two forms of PTEN expression and the follow-up results when p5 3 negative expression (χ2 = 35.95, P <0.05), p5 3 positive expression , There was no significant difference between the two forms of PTEN expression and the follow-up results (χ2 = 0.175, P = 0.997). p5 3 and PTEN expression and follow-up results of two-factor logistic regression analysis, only PTEN expression into the regression model, p5 3 did not enter the model, PTEN expression and follow-up results were positively correlated. Conclusion p5 3, PTEN osteosarcoma expression and its role in the prognosis of PTEN p5 3 greater role than