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目的 观察他汀类降脂药辛伐他汀对冠心病慢性心力衰竭预后的影响。方法 2001-12~2003-12广东省潮州市中心医院,冠心病慢性心力衰竭患者114例,随机分成辛伐他汀组(59例),对照组(55例)。所有心力衰竭患者均常规治疗,治疗组加用辛伐他汀20mg,每晚1次。治疗2个月后复查血脂常规、C反应蛋白(C- RP)、左室射血分数(LVEF)。观察所有患者的住院次数、总日数、病死率。结果 辛伐他汀治疗组及对照组比较,治疗2个月后,血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL- C)、C -RP均有不同程度的降低,LVEF则有明显提高。治疗组和对照组比,住院次数和总日数减少,但差异无显著性(P>0. 05);病死率明显降低,两组相比差异有非常显著性(P<0. 01)。结论 辛伐他汀治疗冠心病慢性心力衰竭能够改善患者的预后。
Objective To observe the effect of statin lipid lowering simvastatin on the prognosis of patients with coronary heart disease and chronic heart failure. Methods From Dec.1001 to Dec 2003, 114 patients with chronic heart failure of coronary heart disease were randomly divided into simvastatin group (n = 59) and control group (n = 55). All patients with conventional heart failure treatment, the treatment group plus simvastatin 20mg, 1 night. Blood routine, C-reactive protein (C-RP) and left ventricular ejection fraction (LVEF) were examined after 2 months of treatment. All patients were observed in the number of hospitalizations, the total number of days, mortality. Results Compared with the control group, the levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and C -RP in the simvastatin group and the control group decreased to some extent and LVEF increased significantly . The treatment group and the control group, the number of hospitalizations and the total number of days decreased, but no significant difference (P> 0.05); mortality was significantly lower, the difference between the two groups was significant (P <0.01). Conclusion Simvastatin in patients with coronary heart disease and chronic heart failure can improve the prognosis of patients.