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目的:探讨成骨细胞特异性转录因子2(runt-related transcription factor 2,Runx2)在乳腺癌组织中的表达及临床意义。方法:采用免疫组织化学法检测Runx2在乳腺浸润性导管癌和癌旁乳腺组织中的表达情况及其与乳腺癌临床病理特征间的关系。结果:Runx2在乳腺浸润性导管癌及癌旁乳腺组织中的阳性表达率分别为69.52%(73/105)和8.57%(9/105),乳腺浸润性导管癌组Runx2的阳性表达率显著高于癌旁乳腺组织,差异具有统计学意义,而且Runx2在乳腺浸润性导管癌中的表达与雌激素受体(estrogen receptor,ER)呈负相关。Runx2的表达与乳腺癌的组织学分级、淋巴结转移及临床分期相关,而与患者年龄及肿瘤大小无关。结论:Runx2可能参与了乳腺癌的发生,而且在ER阴性乳腺癌的发生过程中可能发挥了更加重要的作用。Runx2与乳腺癌的恶性程度、浸润、转移有关,提示Runx2可能成为乳腺癌患者预后评估的重要指标之一。
Objective: To investigate the expression of Runx2 in breast cancer and its clinical significance. Methods: Immunohistochemistry was used to detect Runx2 expression in invasive ductal carcinoma and adjacent normal breast tissue and its relationship with clinicopathological features of breast cancer. Results: The positive expression rates of Runx2 in breast invasive ductal carcinoma and adjacent normal breast tissue were 69.52% (73/105) and 8.57% (9/105), respectively. The positive expression rate of Runx2 in invasive ductal carcinoma of breast tissue was significantly higher The expression of Runx2 in invasive ductal carcinoma of the breast was negatively correlated with the estrogen receptor (ER). Runx2 expression was correlated with histological grade, lymph node metastasis and clinical stage in breast cancer, but not with patient’s age and tumor size. Conclusion: Runx2 may be involved in the development of breast cancer and may play a more important role in the pathogenesis of ER-negative breast cancer. Runx2 is associated with the malignancy, infiltration and metastasis of breast cancer, suggesting Runx2 may be one of the important prognostic factors in breast cancer patients.