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自从1929年Fleming氏发現青霉素并于1940年經Florey氏应用于临床以来,抗菌素已达3000种以上,晚近,由于人体免疫学和类固醇激素的进展,抗菌素常与自家菌苗、球蛋白、杀菌素和激素併用,治疗一些单独应用抗菌素而失敗的病例。抗菌素的应用階段 1.单独使用青霉素对抗一种或一族細菌。 2.一种抗菌素对抗多种細菌,如广譜抗菌素四圜素族(金霉素、土霉素、四圜素)。 3.多种抗菌素合用以对抗混合感染及延迟抗药菌株的产生。
Since Fleming’s discovery of penicillin in 1929 and its application to the clinic by Florey’s in 1940 has resulted in more than 3,000 antibiotics, and recently, due to advances in human immunology and steroid hormones, antibiotics often interact with their own bacterins, globulins, And hormones and treatment, the treatment of some cases of antibiotic failure alone. Antimicrobial Application Phase 1. Penicillin alone against one or a group of bacteria. 2. An anti-bacterial against a variety of bacteria, such as the broad-spectrum antibiotic tetracyacins (chlortetracycline, oxytetracycline, tetracene). A variety of antibiotics combined to combat mixed infections and delay the generation of drug-resistant strains.