【摘 要】
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Peptide 6A (P6A), one of the products degraded from fibrinogen β chain, which can increase CPF and inhibit thrombosis significantly, is a potential thrombodas
【机 构】
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College of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, PRC,College of Pharm
【出 处】
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Progress in Natural Science
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Peptide 6A (P6A), one of the products degraded from fibrinogen β chain, which can increase CPF and inhibit thrombosis significantly, is a potential thrombodasiser. In this paper P6A was selected as the lead compound and the residue Ala’ was substituted. Thus the derivatives Lys1, Arg1, Asp1, Asn1, Glu1, Gin1 and Gly1-P6A were synthesized. The bioassay indicates that the substitution of amino acid with acidic or basic side chain at position 1 of P6A will decrease the vasodilatation of P6A and the substitution of amino acid with amide side chain at this position of P6A may increase the activity significantly.
Peptide 6A (P6A), one of the products degraded from fibrinogen β chain, which can increase CPF and inhibit thrombosis significantly, is a potential thrombodasiser. The bioassay indicates that the substitution of amino acid with acidic or basic side chain at position 1 of P6A will decrease the vasodilatation of P6A and the substitution of amino acid with amide side chain at this position of P6A may increase the activity significantly.
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