致密物沉积病(dense deposit disease,DDD)是病理学诊断名称。仅指大量高电子密度的致密物在肾小球及视网膜毛细血管基膜内聚集而引发的一组疾病(图1)。由于DDD在临床表现及肾组织病理形态学改变与传统观念的膜增殖性肾小球肾炎(MPGN)极为相似[如两者临床表现均为中至大量蛋白 Dense deposit disease (dense deposit disease, DDD) is the pathological diagnosis of the name. Only a large number of high electron density of dense objects in the glomerular and retinal capillary basement membrane aggregation caused a group of diseases (Figure 1). Due to the clinical manifestations of DDD and renal histopathological changes and the traditional concept of membrane proliferative glomerulonephritis (MPGN) are very similar to [such as the clinical manifestations of both medium to large amounts of protein