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骨密度降低可引起老年人(尤其是老年妇女)自发性骨折。1983年,在美国有130万人因骨质疏松而致骨折。到2030年,65岁以上的老年人中的骨质疏松约增加一倍,这将日益成为医疗、社会和经济方面的共同问题。用双光束吸收仪进行的横断面调查表明,20～40岁起,随着年龄的增长,椎骨骨质量逐渐减少,一生中,女性减少42%,男性仅减少10%。目前认为,雌激素的减少是自发性骨质疏松的原因,其它因素尚有膳食钙的摄入与吸收、运动及其它激素等。钙的吸收肠道以主动运转、被动扩散和渗透的形式吸收钙。维生素D的代谢产物1,25(OH)_2D对调节肠道钙和磷的主动运转起重要作用。维
Decreased bone mineral density can cause spontaneous fractures in the elderly, especially in older women. In 1983, 1.3 million people in the United States fractured because of osteoporosis. By about 2030, the doubling of osteoporosis among the elderly over the age of 65 will increasingly become a common medical, social and economic issue. Cross-sectional investigation with a dual-beam absorptometer showed that from the age of 20 to 40 years, vertebral bone mass gradually decreased with age, with 42% fewer women and 10% fewer men. Now that the reduction of estrogen is the cause of spontaneous osteoporosis, other factors are dietary calcium intake and absorption, exercise and other hormones. The calcium-absorbing gut absorbs calcium in active form, passive diffusion and osmosis. 1,25 (OH) _2D, a metabolite of vitamin D, plays an important role in the regulation of intestinal Ca and P active transport. dimension