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脂肪肉瘤是最常见的软组织恶性肿瘤,其中去分化脂肪肉瘤与差分化肉瘤、非典型脂肪瘤性肿瘤/高分化脂肪肉瘤与良性脂肪源性肿瘤常常难以鉴别。本文从免疫组化、分子病理学两个层面,对细胞周期素依赖性激酶4及小鼠双微体基因2在其诊断及鉴别诊断中的应用做一综合介绍。
Liposarcoma is the most common malignancy of soft tissue, of which dedifferentiated liposarcoma and differentiated sarcoma, atypical lipoma / hyperplastic liposarcoma and benign lipogenic tumors are often difficult to identify. In this review, we summarize the applications of cyclin-dependent kinase 4 and mouse dual-microgene 2 in their diagnosis and differential diagnosis from the aspects of immunohistochemistry and molecular pathology.