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以病例—病例研究设计对 118例临床确诊的冠心病(CHD)患者和 5 3例血管痉挛性CHD(X综合征 )患者的胰岛素抵抗 (IR)和相关危险因素的关系进行了调查和分析。 88例胰岛素敏感性指数≤ 2 5 %百分位点和 /或胰岛素水平≥ 75 %百分位点纳入IR组 ,其它 83例纳入非IR组。单因素分析显示 :吸烟和超重或肥胖的优势比 (OR)分别为 2 2 9(1 0 6～ 4 98)和1 89(0 98～ 3 36 ) ,其它因素无明显统计学联系 :计量资料的均数比较显示 :IR组的体重指数和每日吸烟量显著高于非IR组 :多因素Logistic回归显示 :被筛选进入回归方程的变量为体重指数和吸烟史。上述结果提示 ,吸烟和超重可能是导致CHD患者发生IR的重要危险因素
The case-case study design was used to investigate and analyze the association between insulin resistance (IR) and risk factors in 118 clinically diagnosed patients with coronary heart disease (CHD) and 53 patients with vasospastic CHD (syndrome X). 88 patients with insulin sensitivity index ≤ 25% percentile and / or insulin level ≥ 75% percentile were included in the IR group, the other 83 cases were included in the non-IR group. Univariate analysis showed that odds ratio (OR) between smoking and overweight or obesity was 229 (106 ~ 988) and 1 89 (988 ~ 366), respectively. Other factors were not statistically related to the measurement data The body weight index and daily cigarette smoking in the IR group were significantly higher than those in the non-IR group: Multivariate Logistic regression showed that the variables screened into the regression equation were body mass index and smoking history. The above results suggest that smoking and overweight may be important risk factors for IR in CHD patients