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目的分析原发灶不明癌的临床特点,探讨其治疗及预后。方法回顾性分析了2003年8月至2007年3月期间收治的24例原发灶不明癌患者,分析病理类型、治疗方式、全身化疗周期数、受累器官数目等与生存期的关系。结果病理类型、治疗方式、化疗周期数、累及器官数目等均对生存期有一定影响,但运用Cox比例风险回归模型对预后因素进行分析,结果显示只有治疗方式(P=0.011)和化疗周期数(P=0.008)是影响预后的独立因素。结论采用紫杉类加铂类化疗及全身热疗的患者和化疗周期数达3个或以上的患者生存期相对较长。
Objective To analyze the clinical features of unknown primary carcinoma and to investigate its treatment and prognosis. Methods A retrospective analysis of 24 patients with primary malignant tumor admitted between August 2003 and March 2007 was performed to analyze the relationship between pathological type, treatment modalities, the number of cycles of systemic chemotherapy, the number of affected organs and the survival time. Results The pathological types, treatment modalities, the number of chemotherapy cycles and the number of involved organs all had some effects on the survival. However, the Cox proportional hazards regression model was used to analyze the prognostic factors. The results showed that only the treatment modalities (P = 0.011) (P = 0.008) were independent prognostic factors. Conclusions Patients treated with taxane plus platinum-based chemotherapy and systemic hyperthermia and patients with 3 cycles or more of chemotherapy cycles have relatively longer survival.