目的　探讨应用乳腺摄片结合立体定位系统 ,对不可触及的乳腺病变进行细针定位乳腺活检术的价值。方法　回顾性总结分析对 42例乳腺摄片发现不可触及的乳腺病变病人所实行的细针定位乳腺活检术。结果　 42例病人中 ,发现早期乳腺癌 8例 (19% ) ,其中原位癌 2例 ,临床Ⅰ期 4例 ,临床Ⅱ期 2例 ,明显高于临床发现的乳腺癌。另外乳腺纤维瘤 17例 ,导管内乳头状瘤 4例 ,乳腺囊肿 2例 ,乳腺腺病 10例 ,不明原因钙化灶 1例。其中乳腺癌、纤维瘤、导管内乳头状瘤、乳腺囊肿均有明确手术指征 ,占 73 8%。结论　对不可触及乳腺病变应积极活检 ,而细针定位活检是首选有效的方法。 Objective To evaluate the value of fine needle biopsy in breast biopsy with mammography combined with stereotaxic system for non-palpable breast lesions. Methods Retrospective analysis of 42 cases of breast film found inaccessible breast lesions implemented by the needle positioning breast biopsy. Results Among the 42 patients, 8 cases (19%) of early breast cancer were found, of which 2 were in situ carcinoma, 4 in clinical stage Ⅰ and 2 in clinical stage Ⅱ, which were significantly higher than those in clinical stage. In addition, 17 cases of breast fibroids, 4 cases of intraductal papilloma, 2 cases of breast cysts, breast adenosis in 10 cases, 1 case of unexplained calcification. Including breast cancer, fibroids, intraductal papilloma, breast cysts have clear indications for surgery, accounting for 73 8%. Conclusions Positive biopsy should be performed on non-palpable breast lesions, and fine needle biopsy is the first choice and effective method.