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SOCS(Suppressor of cytokine signaling),是一种细胞因子信号通路抑制蛋白,目前认为该蛋白家族可以调节LIF(Leukemia inhibitory factor)、G-CSF(Granulocyte colony-stimulating factor)、IL-6(Interleukin-6)、IL-10(Interleukin-10)、IFN-λ(interferon-λ)等30多种细胞因子,而这些因子是机体抵抗入侵的外来病原体的主要免疫防御反应。病毒在感染宿主的过程中通过劫持宿主中的SOCS蛋白,从而对细胞中的JAK/STAT、NF-κB等与抗病毒因子调控相关的信号通路以及对T细胞的分化的调控调节病毒感染。近年来,大量的文献证实SOCS蛋白的变化与病毒感染的程度以及愈后的器官损伤具有紧密的联系,使得SOCS蛋白作为抗病毒靶点的研究尤为重要。本文主要讨论SOCS蛋白通过调控JAK-STAT、NF-κB等信号通路,在病毒感染过程中发挥的作用和作用机制。
SOCS (Suppressor of cytokine signaling), a cytokine signaling pathway inhibitor, is currently believed to regulate LIF (Leukemia inhibitory factor), G-CSF (Granulocyte colony-stimulating factor), Interleukin-6 ), IL-10 (Interleukin-10), and IFN-λ (interferon-λ). These factors are the main immune defenses of the body against invading foreign pathogens. The virus in the process of host infection by hijacking SOCS protein in the host, thereby regulating JAK / STAT, NF-κB and other signal transduction pathways associated with anti-viral factor regulation and differentiation of T cells in the cell regulates viral infection. In recent years, a large number of documents confirm that the change of SOCS protein is closely related to the degree of virus infection and the later organ damage, making the study of SOCS protein as an anti-virus target particularly important. This article mainly discusses SOCS protein through the regulation of JAK-STAT, NF-κB and other signaling pathways in the process of viral infection play a role and mechanism.