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本组使用双盲法观察巯甲丙脯酸的降压效力。选择了16例65～80岁的男女门诊病人,均无明显肾功能损害及其它伴随疾病。先后各接受巯甲丙脯酸及安慰剂治疗4周,剂量为巯甲丙脯酸12.5mg,2次/日,口服,如2周后卧位血压未达160/90mmHg以下,后2周剂量加至25mg,2次/日,口服。结果表明:除去1例对安慰剂不适应和1例使用巯甲丙脯酸期间因慢性十二指肠溃疡常规手术外,其余14例使用安慰剂平均收缩压和舒张压与基础血压相比没有明显差异,但使用巯甲丙脯酸后收缩压和舒张压与基础血压相比显著下降(P<0.001),
This group double-blind observation of captopril antihypertensive efficacy. Sixteen male and female outpatients aged 65-80 years were selected, no obvious renal dysfunction and other accompanying diseases. Were treated with captopril and placebo for 4 weeks, the dose of captopril 12.5mg, 2 times / day, orally, such as 2 weeks after supine blood pressure less than 160 / 90mmHg the following two weeks dose Add to 25mg, 2 times / day, orally. The results showed that except for 1 case of placebo incompatibility and 1 case of captopril due to chronic duodenal ulcer during conventional surgery, the remaining 14 cases of placebo using the average systolic blood pressure and diastolic blood pressure compared with no However, systolic and diastolic blood pressures decreased significantly (P <0.001) compared with baseline blood pressure after the use of captopril