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采用冷冻-解冻交联聚乙烯醇(PVA),海藻酸钠(SA)交联Ca2+制备聚乙烯醇/海藻酸钙(PVA/Alg-Ca)互穿网络水凝胶。探究了影响混合水凝胶pH敏感性及平衡溶胀比的原因,考察了冷冻-解冻循环次数、Ca2+浓度、海藻酸钠含量对凝胶弹性模量(E)的影响。利用回归分析建立数学模型,实现对E定量控制,模拟细胞在体内生长的生物物理环境。数学模型模拟的相对误差不超过0.1,可实现对PVA/Alg-Ca互穿网格水凝胶力学性能的定量控制。
Polyvinyl alcohol / calcium alginate (PVA / Alg-Ca) interpenetrating network hydrogels were prepared by freeze-thaw crosslinking polyvinyl alcohol (PVA) and sodium alginate (SA) The reasons that affect the pH sensitivity and the equilibrium swelling ratio of the hydrogels were investigated. The effects of freezing-thawing cycles, Ca2 + concentration and sodium alginate content on the gel elastic modulus (E) were investigated. Using regression analysis to establish a mathematical model to achieve quantitative control of E, to simulate the cell growth in vivo biophysical environment. The relative error of mathematical model simulation is less than 0.1, which can quantitatively control the mechanical properties of PVA / Alg-Ca interpenetrating grid hydrogels.