目的　探讨QRII号对单纯肥胖性大鼠肥胖的影响。方法　采用高脂饲料喂养建立单纯肥胖性大鼠模型。测定体重、Lee’s指数、脂肪重量形态学指标 ,判定其减肥效果 ;测定血清瘦素、胰岛素、血糖等 ,判定其对肥胖的影响 ;测定血清TC、TG、LDL、HDL等指标 ,判定其对血脂影响。结果　QRII号大、中剂量组减肥疗效较好。减肥同时血脂、血糖有不同程度降低。减肥有效时 ,血清Leptin、胰岛素水平明显降低。结论　QRII号具有显著的减肥降脂作用 ,其作用可能是多方面多机制调节的结果。 Objective To investigate the effect of QRII on obesity in simple obese rats. Methods Fat rats were fed with high fat diet. The body weight, Lee’s index and fat weight and morphological indexes were measured to determine the effect of weight loss. Serum leptin, insulin, blood glucose and other factors were determined to determine their effect on obesity. Serum TC, TG, LDL, HDL and other indicators were determined, influences. Results QRII large and medium dose group better efficacy of weight loss. At the same time lose weight lipids, blood glucose levels have been reduced to varying degrees. Effective weight loss, serum Leptin, insulin levels decreased significantly. Conclusion QRII has significant lipid-lowering effect on weight loss, its role may be multi-mechanism adjustment results.