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目的：：探讨妊娠糖尿病孕妇胎盘母体面与胎儿面中脂肪因子水平的变化及其临床意义.方法：选择2013年6月至2015年6月期间我院收治的30例妊娠糖尿病(GDM)孕妇为观察组、30例健康孕妇(葡萄糖耐量正常)为对照组.两组分娩后,检测白细胞介素(Interleukin,IL－6)、肿瘤坏死因子－α(tumor necrosis factor－α,TNF－α)、脂联素(Adiponectin,APN)、瘦素(Leptin,LEP )指标的胎盘的胎儿面和母体面含量水平,并作组间比较.结果：观察组 LEP 、TNF－α、IL－6指标胎儿面、母体面均显著高于对照组,组间差异 P ＜0．05.观察组 APN 胎儿面、母体面均显著低于对照组,组间差异 P ＜0．05.结论：妊娠糖尿病孕妇胎盘母体面与胎儿面中脂肪因子水平与正常孕妇存在一定差异性,探讨两者关系将有助于提高 GDM 诊疗水平.“,”Objective:To investigate the changes and clinical significance of the level of maternal fetal fat factor in the placenta of pregnant women with gestational diabetes mellitus.Methods:30 cases of gestational diabetes mellitus (GDM)in our hospital from June 201 3 to June 201 5 were selected as observation group,and 30 healthy pregnant women (normal glucose tolerance)were selected as control group.After delivery,the two groups were detected tumor,Interleukin (IL-6),tumor necrosis factor alpha (necrosis factor-),(TNF-),adiponectin (Adiponectin,APN),leptin (Leptin,LEP)in the placenta of fetal and maternal levels,and compared between groups. Results:the observation group LEP,TNF- alpha,IL- 6 index of fetal face,maternal side were significantly higher than the control group,the difference between the group P < 0.05.The observation group APN fetal face,maternal side were significantly lower than the control group,the difference between the groups P < 0.05.Conclusion::there are some differences between the placental mother and the fetal face in the pregnant women with gestational diabetes mellitus,and the relationship between them will be helpful to improve the level of diagnosis and treatment of GDM.