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目的探讨冠心病患者血清鸢尾素(Irisin,一种肌肉因子)水平与冠状动脉病变严重程度的相关性。方法连续入选于西京医院诊断为冠心病的患者249例,其中稳定型心绞痛(SAP)30例、不稳定型心绞痛(UAP)76例、急性心肌梗死(AMI)143例,收集一般临床资料。采用ELISA方法检测空腹血清Irisin水平,并将研究对象分为低Irisin组(Irisin≤2.3μg/ml)和高Irisin(Irisin>2.3μg/ml)组,比较两组受试者冠脉病变严重程度,分析血清Irisin浓度和冠脉病变严重程度的相关性。结果低Irisin组和高Irisin组相比,具有男性比例高、高肌钙蛋白I(Tn I)、高CK-MB、高肌红蛋白和低左室射血分数(LVEF)的临床特点(均P<0.05),且冠脉病变严重程度(平均病变支数,Gensini评分)显著性加重(P<0.05,P<0.01);多元逐步回归分析显示,病变血管支数和Gensini评分是影响血清Irisin水平的独立因素(P<0.01);Gensini评分和血清Irisin水平呈负相关(r=-0.183,P<0.01)。结论冠心病患者血清Irisin浓度与冠脉病变程度具有一定的相关性。
Objective To investigate the correlation between the level of serum irisin (a muscle factor) and the severity of coronary artery disease in patients with coronary heart disease. Methods A total of 249 patients with coronary heart disease were enrolled in Xijing Hospital. Among them, 30 patients had stable angina pectoris (SAP), 76 patients had unstable angina pectoris (UAP) and 143 patients had acute myocardial infarction (AMI). General clinical data were collected. The level of Irisin in fasting serum was detected by ELISA, and the subjects were divided into low Irisin group (Irisin≤2.3μg / ml) and high Irisin (Irisin> 2.3μg / ml) group. The severity of coronary artery disease was compared between the two groups , The correlation between serum Irisin concentration and the severity of coronary artery disease was analyzed. Results The clinical features of high Irisin group and high Irisin group were higher than those of the high Irisin group (P <0.05). The clinical features of high Irisin group, high Troponin I, High CK-MB, High Myoglobin and Low LVEF (P <0.05, P <0.05). The severity of coronary lesions (mean lesion count, Gensini score) was significantly higher (P <0.05, P <0.01). Multiple regression analysis showed that the number of vascular lesions and Gensini score (P <0.01). There was a negative correlation between Gensini score and serum Irisin level (r = -0.183, P <0.01). Conclusion The serum concentration of Irisin in coronary heart disease patients has a certain correlation with the degree of coronary artery disease.