KBQ是以大豆磷脂为主要成份的营养液.近年来研究结果表明,大豆磷脂具有防治高脂血症、抗衰老等作用.本文就其毒性及功效进行了实验研究.1 材料与方法1.1 样品 KBQ营养液由滋补保健食品厂提供,乳白色粘稠液体,比重0.837.以生理盐水稀释至各试验选用的剂量.1.2 动物 选用白求恩医科大学动物室繁殖的健康昆明种小白鼠.1.3 小鼠经口急性毒性试验 小鼠40只,雌雄各半,体重19～22.5g,以 20.9g/kg剂量经口灌胃,灌胃量为 0.25ml/10g,观察动物染毒后状态,观察期两周.1.4 小鼠骨髓嗜多染红细胞微核试验 选用20～25g昆明种小鼠60只,雌雄各半,分6组,每组10只.按10450,5275,2638mg/kg体重灌胃给药,另设阴性对照及阳性(环磷酰胺30mg/kg)对照.两次给药间隔24小时,第2次给药后6小时取材.取股骨骨髓涂片,Giemsa染色,每只动物计数1000个嗜多染红细 KBQ is a soybean phospholipid as the main component of nutrient solution.In recent years, the results show that soybean phospholipids with the prevention and treatment of hyperlipidemia, anti-aging effect.In this paper, the toxicity and efficacy of an experimental study.1 Materials and Methods 1.1 Sample KBQ Nutrient solution provided by the nourishing health food factory, milky white viscous liquid, the proportion of 0.837.Diluted with saline to the dose of each test.1.2 animal selection Bethune Medical University breeding room of healthy Kunming mice.1.3 mice were orally acute Toxicity test mice 40, male and female, weight 19 ~ 22.5g, 20.9g / kg dose by oral gavage, gavage 0.25ml / 10g, the observed state of the animals after exposure, observation period of two weeks.1.4 Mouse bone marrow polychromatic erythrocyte micronucleus test 60 Kunming mice 20 ~ 25g, male and female, divided into 6 groups, each group of 10. According to 10450,5275,2638mg / kg body weight intragastric administration, the other set Negative control and positive (cyclophosphamide 30mg / kg) control .Two administration interval of 24 hours, 6 hours after the second administration of the material taken femoral bone marrow smear, Giemsa staining, each animal counts 1000 polychrome Red fine