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目的观察大枣预处理对酒精性肝病小鼠血清AST、ALT,肝组织病理及肝组织细胞色素P4502e1(cytochrome P4502e1,CYP2E1)和肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)表达的影响。方法 88只昆明种小鼠随机分成空白对照组(简称对照组,28只)、模型组(32只)和大枣治疗组(简称治疗组,28只),模型组和治疗组采用酒精灌胃的方法复制动物模型,对照组应用蒸馏水代替。4周时治疗组灌胃大枣提取物,其余组均灌胃等量蒸馏水。共计12周。观察应用大枣后,酒精性肝病小鼠血清AST、ALT,肝组织病理及肝组织CYP2E1和TNF-α的表达。结果与模型组比较,治疗组血清AST、ALT水平下降,肝组织病理改善,肝组织CYP2E1和TNF-α表达下降,差异有统计学意义(P<0.05)。结论大枣对酒精性肝病有一定疗效。
Objective To observe the effect of jujube pretreatment on serum AST, ALT, liver histopathology and the expression of cytochrome P4502e1 (CYP2E1) and tumor necrosis factor-α (TNF-α) in mice with alcoholic liver disease influences. Methods Totally 88 Kunming mice were randomly divided into blank control group (n = 28), model group (n = 32) and jujube treatment group (n = 28) The animal model was replicated, while the control group was replaced by distilled water. At 4 weeks, the jujube extract was given to the treatment group and the other groups were given the same amount of distilled water. Total 12 weeks. The serum AST, ALT, liver histopathology and the expression of CYP2E1 and TNF-α in liver of alcoholic liver disease were observed after applying jujube. Results Compared with the model group, the levels of serum AST and ALT in the treatment group decreased, the pathological changes of the liver tissue were improved, and the expression of CYP2E1 and TNF-α in the liver tissue decreased. The difference was statistically significant (P <0.05). Conclusion jujube has a certain effect on alcoholic liver disease.