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目的 :研究应用以大剂量顺铂为主联合术前诱导化疗治疗口腔颌面部鳞癌和腺上皮癌的近期疗效和安全性。方法 :对 5 6例鳞癌 ,采用 VCP联合化疗方案 ,对 36例腺上皮癌采用 VC5 - Fu方案。化疗结束后 ,按照国际通用标准 ,对所治疗病例进行近期疗效分析 ,对药物的毒副反应进行观察。结果 :VCP方案治疗 5 6例鳞癌的近期有效率 (缓解率 )为 83.9% ,VC5 - Fu方案治疗 36例腺上皮癌的近期有效率为 6 3.9%。两组的总有效率为 73.9%。化疗的主要毒副反应为呕吐反应、骨髓抑制等。结论 :以大剂量顺铂为主联合术前诱导化疗的近期疗效是肯定的 ,在口腔颌面部晚期恶性肿瘤的综合治疗中应该推广使用。加强对机体的保护性措施 ,可提高联合诱导化疗的安全性和疗效。
Objective: To study the application of high-dose cisplatin-based preoperative induction chemotherapy in the treatment of oral and maxillofacial squamous cell carcinoma and glandular epithelial carcinoma in the short term efficacy and safety. Methods: Fifty - six squamous cell carcinomas were treated with VCP combined with chemotherapy, and VC5 - Fu was used in 36 patients with epithelial carcinoma of the gland. After chemotherapy, in accordance with international standards, the treatment of patients with short-term efficacy analysis, the drug side effects were observed. Results: The effective rate (response rate) of VCP regimen in treating 56 cases of squamous cell carcinoma was 83.9%, and that of VC5 - Fu regimen in 36 cases of adenocarcinoma was 6 3.9%. The total effective rate of both groups was 73.9%. The main side effects of chemotherapy for vomiting, bone marrow suppression and so on. CONCLUSION: The short-term curative effect of preoperative induction chemotherapy combined with high-dose cisplatin is positive. It should be widely used in the comprehensive treatment of advanced oral and maxillofacial malignant tumors. Strengthen the protective measures on the body can improve the safety and efficacy of combined induction chemotherapy.