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目的研究2型糖尿病患者血清抵抗素、瘦素、脂联素水平与颈动脉斑块形成的关系。方法选择2型糖尿病患者(T2DM)60例作为试验组,根据是否伴颈动脉斑块分为斑块组和无斑块组;另选取同期健康体检人群50例作为正常组。用酶联免疫吸附法(ELISA)检测2组人群血清抵抗素、瘦素、脂联素水平,并对T2DM患者进行颈动脉超声检查。结果试验组患者血清抵抗素、瘦素水平分别为(4.60±2.05),(3.17±0.11)ng·mL~(-1),显著高于正常组的(1.80±1.33),(0.95±0.04)ng·mL~(-1);而试验组脂联素水平为(1.62±0.13)μg·mL~(-1),则明显低于正常组的(5.35±0.14)μg·mL~(-1),差异都有统计学意义(均P<0.01)。在T2DM患者中,有斑块组血清的抵抗素、瘦素水平分别为(5.17±1.18),(3.51±0.12)ng·mL~(-1),显著高于无斑块组的(3.01±1.25),(1.33±0.15)ng·mL~(-1),而有斑块组脂联素水平为(1.35±0.06)μg·mL~(-1),则明显低于无斑块组的(2.81±0.10)μg·mL~(-1),差异都有统计学意义(均P<0.01)。血清抵抗素(OR=2.19,P<0.05,95%CI:0.812~3.581)、瘦素(OR=4.54,P<0.05,95%CI:1.757~11.748)及脂联素(OR=3.94,P<0.05,95%CI:1.396~11.141)的95%置信区间的结果表明,在T2DM患者中,血清抵抗素、瘦素水平呈明显正相关(P<0.05),抵抗素与脂联素、瘦素与脂联素水平均呈明显负相关(P<0.05)。结论血清抵抗素和瘦素水平升高、脂联素水平降低是T2DM患者颈动脉斑块形成的独立危险因素,其可作为诊断T2DM和颈动脉斑块形成的重要参考指标。
Objective To investigate the relationship between serum resistin, leptin and adiponectin levels and carotid artery plaque formation in type 2 diabetic patients. Methods Sixty patients with type 2 diabetes mellitus (T2DM) were selected as the experimental group and divided into plaque group and non-plaque group according to whether carotid artery plaque was included or not. Another 50 healthy subjects were selected as the normal group. Serum resistin, leptin and adiponectin levels were measured by enzyme-linked immunosorbent assay (ELISA) in 2 groups of patients. Carotid ultrasonography was performed on T2DM patients. Results The levels of serum resistin and leptin in test group were (4.60 ± 2.05) and (3.17 ± 0.11) ng · mL -1, respectively, which were significantly higher than those in normal group (1.80 ± 1.33, 0.95 ± 0.04) ng · mL -1, while the level of adiponectin in the experimental group was (1.62 ± 0.13) μg · mL -1, which was significantly lower than that of the normal group (5.35 ± 0.14 μg · mL -1 ), The differences were statistically significant (both P <0.01). In T2DM patients, the levels of resistin and leptin in plaque group were (5.17 ± 1.18), (3.51 ± 0.12) ng · mL -1, respectively, which were significantly higher than those in plaque group (3.01 ± 1.25), (1.33 ± 0.15) ng · mL -1, while the level of adiponectin in plaque group was (1.35 ± 0.06) μg · mL -1, which was significantly lower than that in non-plaque group (2.81 ± 0.10) μg · mL -1, respectively (all P <0.01). Serum resistin (OR = 2.19, P <0.05,95% CI: 0.812-3.581), leptin (OR = 4.54, P <0.05,95% CI 1.757-11.748) and adiponectin <0.05, 95% CI: 1.396-11.141) showed that there was a significant positive correlation between serum resistin and leptin levels in T2DM patients (P <0.05), resistin and adiponectin, The levels of adiponectin and adiponectin were negatively correlated (P <0.05). Conclusion Serum resistin and leptin levels are elevated, and adiponectin level is an independent risk factor for carotid plaque formation in T2DM patients. It may serve as an important reference for diagnosis of T2DM and carotid plaque formation.