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近十年来,由于使用抗肿瘤的药物增加,使恶性肿瘤患者的生命有所延长,同时由于用药时间长,对诱发眼部副作用的化疗药物也有了更进一步的认识。这类药物中有许多种药能引起眼部刺激症状的加重(氟脲嘧啶、氨甲喋呤)、泪小管纤维变性伴有泪溢(氟脲嘧啶)、视网膜病变(氯本二氯乙烷、三苯氧胺)、角膜混浊(三苯氧胺)、白内障(白消安、氨甲喋呤)和视神经或眼球运动异常(卡氮芥、长春碱、长春新碱)。总的来说,这些不良作用并不常见,但
The past decade, due to the use of anti-tumor drugs to increase the life of patients with malignant tumors has been extended, while the medication for a long time, induced eye side effects of chemotherapy drugs have been further understanding. Many of these drugs have been shown to cause aggravation of ocular irritation (fluorouracil, methotrexate), fibrosis of the lacrimal duct with diffusor (fluorouracil), retinopathy (chlorinated dichloroethane, tamoxifen) , Corneal opacity (tamoxifen), cataracts (busulfan, methotrexate) and optic nerve or ocular motility disorders (carmustine, vinblastine, vincristine). In general, these adverse effects are uncommon, however