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目的:研究复方山豆根口服液治疗咽炎的药效学作用。方法:以小白鼠为实验对象,口服法给药,消炎痛为阳性对照药,以醋酸所致扭体反应为镇痛指标,以二甲苯所致小鼠耳廓肿胀为消炎指标。结果:本品大中小剂量组均有镇痛作用,大剂量组与消炎痛组相当,维持时间长达6.5 h 以上;各剂量组均有明显的消炎作用,并有一定的量效关系,维持时间长达6.5 h 以上。结论:复方山豆根口服液用于治疗咽炎,有一定的疗效。
Objective: To study the pharmacodynamic effects of compound Shandougen oral liquid on pharyngitis. METHODS: The mice were used as experimental subjects and were orally administered. Indomethacin was a positive control drug. The writhing response caused by acetic acid was used as an analgesic indicator. The mouse ear swelling caused by xylene was used as an anti-inflammatory indicator. Results: This product has analgesic effect in large, medium and small dose groups. The high-dose group is equivalent to indomethacin group, and it lasts for more than 6.5 hours. Each dose group has obvious anti-inflammatory effect and has a certain dose-effect relationship. , Maintain for more than 6.5 h. Conclusion: Compound Shandougen oral liquid has a certain curative effect in the treatment of pharyngitis.