论文部分内容阅读
目的探讨血清尿酸(UA)、尿液肾损伤分子-1(KIM-1)在妊娠期糖尿病(GDM)早期肾损害诊断中的应用价值。方法选取GDM患者65例(GDM组),正常孕妇65例(正常孕妇组),未孕妇女60例(健康未孕组),应用氧化酶法检测UA浓度,采用ELISA法检测尿KIM-1水平,检测3组UA、KIM-1水平,对比正常孕妇和GDM患者中孕、晚孕期的UA、KIM-1水平,分析血清UA与KIM-1的相关性。结果 GDM组血清UA、KIM-1水平均高于正常孕妇组和健康未孕组,且正常孕妇组高于健康未孕组,差异均有统计学意义(P<0.05);正常孕妇中孕亚组、正常孕妇晚孕亚组及GDM中孕亚组、GDM晚孕亚组血清UA、尿KIM-1水平比较差异均有统计学意义(P<0.05);GDM组血清UA与尿KIM-1水平呈显著正相关(r=0.769,P<0.05)。结论血清UA、尿KIM-1可以检测并反映GDM早期肾损伤,从而降低围生期病死率及母婴并发症,具有重要的临床应用价值。
Objective To investigate the value of serum uric acid (UA) and urine nephrotoxic molecule-1 (KIM-1) in the diagnosis of early renal damage in gestational diabetes mellitus (GDM). Methods 65 cases of GDM patients (GDM group), 65 normal pregnant women (normal pregnant women group), 60 pregnant women (healthy non-pregnant group), UA concentration was detected by enzyme-linked immunosorbent assay. Urinary KIM-1 level . The levels of UA and KIM-1 in three groups were detected. The levels of UA and KIM-1 in pregnant and late pregnancy in normal pregnant women and GDM patients were compared. The correlation between serum UA and KIM-1 was analyzed. Results The levels of serum UA and KIM-1 in GDM group were significantly higher than those in normal pregnant group and healthy non-pregnant group, and were significantly higher in normal pregnant women than in healthy pregnant women (P <0.05) (P <0.05). Serum UA and urine KIM-1 in GDM group were significantly lower than those in GDM group (P <0.05) There was a significant positive correlation (r = 0.769, P <0.05). Conclusions Serum UA and urinary KIM-1 can detect and reflect the early renal injury of GDM, thereby reducing the perinatal mortality and maternal and infant complications and has important clinical value.