【摘 要】
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Dear Editor,rnSperm cooperation has been observed in multiple species(Pizzari and Foster,2008),yet its existence and benefit for reproductive success in mammals remains underexplored.Here,combining tissue-clearing with deep three-dimen-sional (3D) imaging
【机 构】
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State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of S
论文部分内容阅读
Dear Editor,rnSperm cooperation has been observed in multiple species(Pizzari and Foster,2008),yet its existence and benefit for reproductive success in mammals remains underexplored.Here,combining tissue-clearing with deep three-dimen-sional (3D) imaging,we demonstrate that postcopulatory mouse sperm congregate into unidirectional sperm cooper-ative clusters at the utero-tubal junction (UTJ),a key physical barrier for passage into the oviduct.Reducing sperm number in male mice by unilateral vasoligation (Uni-Vas) or busulfan-treatment impairs sperm cluster formation and oviduct entry.
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