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自从1969年利福平问世以来,该药广泛地应用于结核病的治疗,其严重副作用有肝中毒性黄疸,免疫性血小板缺乏症和偶见的溶血,Poole等于1971年首次报告1例利福平治疗的病人发生急性肾衰,以后陆续报告了50例左右利福平引起的急性肾衰病例,著者等报导了因结核病应用利福平治疗的5例病人,2男3女,年龄37～75岁,均经过一段时间的利福平治疗,停药4周～2年,因各种原因又重新服用利福平,单次剂量最小250mg,最大600mg,大都是300mg,服药后15～30分钟后即出现发冷、发热、肌痛、恶
Since the advent of rifampin in 1969, it has been widely used in the treatment of tuberculosis and its serious side effects include hepatotoxic jaundice, immune thrombocytopenia and occasional haemolysis. Poole was the first to report a case of rifampicin in 1971 Of patients with acute renal failure, after another reported 50 cases of acute renal failure caused by rifampicin cases, the authors reported the tuberculosis patients treated with rifampin 5 patients, 2 males and 3 females, aged 37 to 75 years , After a period of rifampicin treatment, withdrawal 4 weeks ~ 2 years, due to various reasons and re-taking rifampicin, a single dose of the smallest 250mg, the largest 600mg, mostly 300mg, after taking 15 to 30 minutes That is, chills, fever, myalgia, evil