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目的探讨分心慢性乙肝肝硬化的临床诊断方法及核酸类似物联合用药治疗效果。方法回顾分析2013年1月-2014年1月间医院46例慢性乙肝肝硬化患者的临床诊断资料,调查分析患者检查和治疗恢复情况,记录数据。结果 46例慢性乙肝肝硬化患者药物治疗1年后,其Child-Pugh评分、乙肝病毒DNA定量和血清肝纤维化相关参数水平均比治疗前降低,治疗前后差异具有统计学意义(P<0.05)。结论临床上可以通过肝功能、血常规、胃镜等联合的检查观察判断患者是否患有肝硬化,临床使用核酸类似物联合用药治疗慢性乙肝肝硬化治疗效果显著,值得临床推广使用。
Objective To explore the clinical diagnosis of distracting chronic hepatitis B cirrhosis and the effect of combination therapy of nucleic acid analogues. Methods The clinical diagnosis data of 46 patients with chronic hepatitis B cirrhosis from January 2013 to January 2014 were retrospectively analyzed. The investigation and treatment recovery were investigated and the data recorded. Results The serum levels of Child-Pugh, hepatitis B virus DNA and serum hepatic fibrosis in 46 patients with chronic hepatitis B cirrhosis after 1 year of treatment were significantly lower than those before treatment (P0.05) . Conclusions Clinically, liver cirrhosis can be judged by liver function test, blood routine examination and gastroscopy. The clinical use of nucleic acid analogs in combination with drugs for treatment of chronic hepatitis B cirrhosis is effective and worthy of clinical promotion.