以妊娠晚期绵羊为研究对象，通过进宫腔手术的方法，从胎羊股动脉插管达腹主动脉（ＡｂｄｏｍｉｎａｌＡｏｒｔａ，ＡＯ）水平，留置导管于胎羊体内，导管经三通管接压力换能器及电磁流量计，连续动态监测胎羊ＡＯ血压，定时抽血作血气分析。手术后经胎羊ＡＯ少量多次注射微球悬液，通过脐动脉进入胎盘阻塞胎盘－胎儿循环，从而建立胎儿窘迫动物模型。通过胎羊血气分析及组织学检查，结果表明：注射微球能够阻塞胎盘，影响胎儿血气和酸碱度的变化，造成一系列符合胎儿窘迫的临床表现。 In the third trimester of pregnancy, the object of this study was to investigate the effect of intrauterine catheterization on the abdominal aorta (AO) Device and electromagnetic flowmeter, continuous dynamic monitoring of fetal sheep AO blood pressure, blood gas regularly for blood analysis. A small amount of microspheres suspension was injected into the placenta through the umbilical artery after the surgery, resulting in the establishment of fetal distress animal model. Fetal blood gas analysis and histological examination, the results showed that: injection of microspheres can block the placenta, affecting fetal blood gas and pH changes, resulting in a series of clinical manifestations in line with fetal distress.