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目的：测定慢性乙肝及肝硬化患者血清胃泌素的水平，探讨胃泌素在该疾病中的临床意义。方法：１５２例慢性乙肝及肝硬化患者治疗前后采用放射免疫法检测血清胃泌素值并观察其变化。结果：１５２例患者中有７９．６０％伴有血清胃泌素值升高，而且随着疾病程度的加重，血清胃泌素值升高显著（Ｐ＜０．０５），重度患者升高最显著（Ｐ＜０．０１）；经过治疗，随着病情好转，血清胃泌素值亦随之下降（Ｐ＜０．０５），中度患者下降最显著（Ｐ＜０．０１）；胃泌素值居高不降者，病情凶险。结论：慢性乙肝及肝硬化患者常伴有血清胃泌素升高，血清胃泌素值的测定可做为慢性乙肝及肝硬化患者病情及预后判断的参考标准。
Objective: To determine the level of serum gastrin in patients with chronic hepatitis B and cirrhosis, and to explore the clinical significance of gastrin in this disease. Methods: Serum gastrin levels were measured by radioimmunoassay in 152 patients with chronic hepatitis B and cirrhosis before and after treatment. Results: Serum gastrin level was increased in 79.60% of 152 patients. Serum gastrin level increased significantly with the severity of disease (P <0.05), and increased in severe patients (P <0.01). After treatment, the serum gastrin value decreased with the improvement of the disease (P <0.05) Prime value does not drop high, dangerous condition. Conclusion: Patients with chronic hepatitis B and cirrhosis often accompanied by elevated serum gastrin, determination of serum gastrin can be used as a reference for the diagnosis of disease and prognosis in patients with chronic hepatitis B and cirrhosis.