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目的探讨癌蛋白HER2在直肠癌组织中表达情况及其意义。方法采用免疫组化SP方法检测直肠癌组织中HER2蛋白的表达。结果本组36例直肠癌患者中有11例表达HER2蛋白(30·6%),当肿瘤浸润至肠壁外或发生淋巴结或肝脏转移时,其HER2蛋白阳性率明显高于无转移或浸润深度未及浆膜层的直肠癌(P<0·05)。晚期直肠癌HER2蛋白阳性率较早期直肠癌为高(P<0·05),而HER2蛋白表达与肿瘤部位、大小及肿瘤细胞分化程度以及患者性别、年龄无明显关系(P>0·05)。结论HER2在直肠癌侵袭性生长或转移中具有一定的促进作用,对预测直肠癌预后有一定帮助。
Objective To investigate the expression of oncoprotein HER2 in rectal cancer and its significance. Methods Immunohistochemical SP method was used to detect the expression of HER2 protein in rectal cancer. Results Of the 36 patients with rectal cancer, 11 cases expressed HER2 protein (30.6%). When the tumor infiltrated outside the intestinal wall or lymph node or liver metastasis, the HER2 protein positive rate was significantly higher than that without metastasis or invasion depth Rectal cancer without serosa (P <0.05). The positive rate of HER2 protein in advanced rectal cancer was higher than that in early rectal cancer (P <0.05), while the expression of HER2 protein had no significant correlation with tumor location, size, tumor differentiation and gender and age (P> 0.05) . Conclusion HER2 may play an important role in the invasive growth or metastasis of rectal cancer and may be helpful in predicting the prognosis of rectal cancer.