简介呼吸道合胞病毒（ＲＳＶ）的生物学特点和疫苗研究的进展。已经和正在研制的 ＲＳＶ疫苗包括：（１）福尔马林灭活ＲＳＶ疫苗；（２）活病毒疫苗，是通过冷传代和温度敏感传代获得的ＲＳＶ减毒活疫苗，其免疫反应与自然感染相似，感染野生型ＲＳＶ不加剧病情，能被动获得ＲＳＶ中和抗体产生保护性免疫反应，是目前正在婴幼儿中试用观察的疫苗；（３）ｃＤＮＡ疫苗，是从ＲＳＶ ｃＤＮＡ克隆中回收具有感染性重组ＲＳＶ的活病毒疫苗，在下呼吸道高度减活，可显著提高对野生型－ＲＳＶ感染的免疫力，安全性好，可构建含有ＲＳＶ Ａ、Ｂ组的 Ｇ基因ｃＤＮＡ２价疫苗；（４）载体疫苗，ＲＳＶ Ｆ、Ｇ嵌合疫苗由表达含有ＲＳＶＦ和Ｇ蛋白的杆状病毒纯化获得；（５）亚单位疫苗，对下呼吸道感染具有保护作用，中和抗体滴度高；（６）合成肽类疫苗等。 Introduction The biological characteristics of respiratory syncytial virus (RSV) and the progress of vaccine research. The RSV vaccines that have been and are being developed include: (1) formalin-inactivated RSV vaccine; (2) live virus vaccine, an attenuated live attenuated RSV vaccine obtained through cold passage and temperature-sensitive passage, whose immune response is associated with natural infection Similarly, infection of wild-type RSV does not exacerbate the disease and can passively obtain a protective immune response against neutralizing antibodies against RSV. Vaccination is currently under trial in infants and young children; (3) cDNA vaccines are recovered from RSV cDNA clones with infectivity Recombinant RSV live virus vaccine, highly deactivated in the lower respiratory tract, can significantly improve the immunity to wild type -RSV infection, safety is good, can construct RSV A, B group G gene cDNA2 price vaccine; (4) vector vaccine , RSV F, G chimeric vaccine purified from baculovirus expressing RSVF and G protein; (5) subunit vaccine, which has protective effect on lower respiratory tract infection and high titer of neutralizing antibody; (6) Vaccines and so on.