毫微粒或胶体载体在生物医学和生物技术领域 ,尤其在靶向药物转运系统方面有广泛的应用。毫微粒静脉注射给药后的体内分布既受毫微粒理化性质的影响 ,又受毫微粒与体内生物环境的相互作用的影响。其中毫微粒的大小是影响体内分布的主要因素 ,不同的粒径将导致不同的靶向部位 ( Nanoparticulate or colloidal carriers are widely used in the fields of biomedicine and biotechnology, especially in targeting drug delivery systems. In vivo distribution of nanoparticles after intravenous administration is affected not only by the physical and chemical properties of the nanoparticles, but also by the interaction between the nanoparticles and the biological environment in vivo. The size of the nanoparticles is the main factor affecting the distribution in the body, different particle size will lead to different target sites