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胰岛素抵抗(IR)及高胰岛素血症是多囊卵巢综合征(PCOS)患者代谢异常的基本特征,也是PCOS患者内分泌代谢紊乱的主要特征之一。肥胖型PCOS患者高胰岛素血症发生率高达75%,非肥胖型PCOS患者约为30%。流行病学调查显示PCOS患者发生2型糖尿病、高血压、冠心病等疾病的风险明显增加,胰岛素抵抗作为PCOS的重要病理生理改变,可能在PCOS的发生发展中起中心环节的作用。本文对此进行了综述。
Insulin resistance (IR) and hyperinsulinemia are the basic characteristics of metabolic abnormalities in patients with PCOS and one of the main features of endocrine and metabolic disorders in patients with PCOS. The incidence of hyperinsulinemia in obese patients with PCOS is as high as 75% and in nonobese PCOS patients is about 30%. Epidemiological survey showed that patients with PCOS patients with type 2 diabetes, hypertension, coronary heart disease and other diseases significantly increased the risk of insulin resistance as an important pathophysiological changes in PCOS may play a central role in the occurrence and development of PCOS. This article reviews this.