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目的 探讨血清神经元特异性烯醇酶 (NSE)和单光子发射计算体层摄影术 (SPECT)脑血流显像在儿童癫持续状态 (SE)中诊断脑损伤的价值。方法 采用ABC ELISA药盒 ,检测SE患儿d1、3、7外周血NSE浓度 ;用同位素99mTco4、ECD显像剂药盒进行脑血流显像。结果 SE患儿血清NSE浓度 15 .13± 6 .2 2 μg/L较正常对照 2 .6 35± 0 .76 5 μg/L明显增高 (P <0 .0 0 1) ;15例受检者SPECT脑血流显像异常率高达 73.4 %。结论 儿童SE存在脑损伤 ,血清NSE检测对诊断脑损伤有重要价值 ,动态检测可帮助判断预后。SPECT脑血流显像对脑损伤诊断有辅助价值 ,在SE病因诊断上有较大参考意义
Objective To investigate the value of serum neuron-specific enolase (NSE) and single-photon emission computed tomography (SPECT) cerebral blood flow imaging in the diagnosis of brain injury in children with status epilepticus (SE). Methods ABC ELISA kit was used to detect NSE concentration in peripheral blood of children with d1, 3 and 7 of SE. Cerebral perfusion imaging was performed with isotope 99mTco4 and ECD imaging kit. Results The serum levels of NSE in children with SE were significantly higher than those of normal controls (15.13 ± 6.22 μg / L vs 2.635 ± 0.76 5 μg / L, P <0.01) SPECT cerebral blood flow imaging abnormal rate as high as 73.4%. Conclusion There is brain injury in children with SE. Serum NSE test has important value in the diagnosis of brain injury. Dynamic detection can help to judge the prognosis. SPECT cerebral blood flow imaging is helpful in the diagnosis of brain injury, and it has great reference value in the diagnosis of SE