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目的分析骨巨细胞瘤(GCT)影像学表现,检测增殖细胞核抗原(PCNA)的表达,评价二者与肿瘤病理分级的关系。方法结合X线平片评分方法,应用免疫组织化学方法对24例GCT肿瘤标本检测PCNA,进行病理分级分析评估。结果应用GCTX线平片评分法,评分低者(<5分)PCNA阳性表达率高(95%),而恶性趋势亦高。全部标本PCNA阳性表达随病理分级增加,PC-NA阳性表达有增高趋势,Ⅱ、Ⅲ级与Ⅰ级有显著性差异(P<0.05),Ⅱ级与Ⅲ级间无显著性差异(P>0.05)。结论GCT依据X线表现对明确术前病理分级、指导临床选择正确的治疗方法有重要意义。
Objective To analyze the imaging features of giant cell tumor of bone (GCT), detect the expression of proliferating cell nuclear antigen (PCNA), and evaluate the relationship between the two and the pathological grade of the tumor. Methods Combined with X-ray film scoring method, 24 cases of GCT tumor specimens were detected by immunohistochemical method for PCNA, and pathological grading analysis was performed. RESULTS: Using the GCTX line-fraction scoring method, PCNA positive expression rate was high (95%) in patients with low scores (<5 points), and the malignant tendency was also high. The positive expression of PCNA in all specimens increased with pathological grade, and the positive expression of PC-NA increased. There was a significant difference between grades II, III, and I (P<0.05). There was no significant difference between grade II and grade III (P>0.05). ). [Conclusion] GCT is of great significance for determining the preoperative pathological grade and guiding the clinical selection of the correct treatment method according to X-ray findings.