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心房纤维性颤动(AF)是最常见的心律失常之一,它是由心房主导环折返引起许多小折返环导致的房律紊乱。而炎症已在AF的发病中发挥作用。黏附分子包括整合素作为早期炎性反应的调控介质和信号介导分子可激活信号转导通路,包括丝裂原活化蛋白激酶和局部黏着斑激酶,而使胶原细胞分泌胶原增多,提示AF心肌纤维化的发生可能与胶原的增加有关。研究整合素与AF心肌纤维化的关系有利于减少心肌纤维化的发生率,从而可以降低AF的发生。
Atrial fibrillation (AF) is one of the most common arrhythmias, and it is caused by the atrophy of the atrial dominant loop that causes many atrophy of the atrophy caused by many small reentry loops. Inflammation has played a role in the pathogenesis of AF. Adhesion molecules, including integrins as early mediators of inflammatory responses and signal-mediated activators of signal transduction pathways, including mitogen-activated protein kinases and focal adhesion kinase, increase collagen secretion in collagen cells, suggesting that AF myocardium fibers The occurrence of degeneration may be related to the increase of collagen. Studying the relationship between integrin and AF myocardial fibrosis is beneficial to reduce the incidence of myocardial fibrosis, which can reduce the occurrence of AF.