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目的:研究艾普拉唑治疗幽门螺杆菌(Hp)阳性十二指肠溃疡的疗效及安全性。方法:将89例经内镜证实的十二指肠溃疡Hp阳性患者随机分成艾普拉唑组49例和奥美拉唑组40例,艾普拉唑组:第1周予艾普拉唑5mg、阿莫西林lg、克拉霉素0.5g,口服,每日2次,以后每日顿服艾普拉唑5mg;奥美拉唑组:第1周以奥美拉唑20mg、阿莫西林lg、克拉霉素0.5g,口服,每日2次,以后每日顿服奥美拉唑20mg,两组疗程均为4周,停药后复查内镜观察溃疡愈合情况,记录症状改善及不良反应情况。结果:治疗后,艾普拉唑组的疼痛消失时间为(1.34±0.5)天,奥美拉唑组为(2.3±1.3)天,两组比较有统计学差异(P<0.05);治疗后2周末与4周末两组的症状消失率、4周溃疡愈合率、总有效率比较均无统计学差异(P>0.05);艾普拉唑组的Hp根除率稍高于奥拉唑组,但无统计学差异,艾普拉唑的不良反应发生率为2.04%,奥美拉唑组为5.00%。结论:艾普拉唑对Hp阳性十二指肠溃疡有较高的治愈率和症状改善率,疗效与奥美拉唑相当,用药后患者疼痛消失时间短于奥美拉唑,艾普拉唑抗Hp活性与奥美拉唑相似,不良反应发生率较奥美拉唑少。
Objective: To study the efficacy and safety of ilaprazole in the treatment of Helicobacter pylori (Hp) -positive duodenal ulcer. Methods: 89 cases of duodenal ulcer confirmed by endoscopy Hp positive patients were randomly divided into Ilaprazole group 49 cases and 40 cases of omeprazole group, Ipralazole group: the first week of ioprazole 5mg, amoxicillin lg, clarithromycin 0.5g, 2 times a day, after daily ioprazole 5mg; omeprazole group: the first week of omeprazole 20mg, amoxicillin lg, clarithromycin 0.5g, orally, 2 times a day, after each daily meal omeprazole 20mg, two courses of treatment were 4 weeks after the withdrawal of the endoscopy to observe the healing of ulcers, to record the symptoms and improve the bad Reaction situation. Results: After treatment, the duration of pain disappearance was (1.34 ± 0.5) days in the Ilaprazole group and (2.3 ± 1.3) days in the omeprazole group, with statistical significance (P <0.05) There was no significant difference in the rate of disappearance of symptoms, the healing rate of 4-week ulcer and the total effective rate between the two groups at the end of 2 weeks and the end of 4 weeks (P> 0.05). Hp eradication rate in Ilaprazole group was slightly higher than that of Olazac group However, there was no statistical difference. The incidence of adverse reactions of Ilaprazole was 2.04% and that of omeprazole group was 5.00%. CONCLUSION: Iprazole has a higher cure rate and improvement rate of symptoms on Hp-positive duodenal ulcer. The curative effect is comparable to that of omeprazole, and the disappearance time of patients after treatment is shorter than that of omeprazole, ioprazole Anti-Hp activity and omeprazole similar adverse reactions occur less than omeprazole.