p16是一种新近发现的抑癌基因,主要在G1期向S期的转换过程中发挥对细胞周期的调节作用,同cyclinD1竞争与周期依赖性蛋白激酶(CDK)4/CDK6结合,抑制其激酶的活性,阻止细胞从G1期进入S期,从而抑制细胞增殖。研究表明其与多种肿瘤的发生相关,以缺失、突变或甲基化的形式广泛存在于多种肿瘤中,并参与肿瘤的发生、发展。现就p16在口腔癌中的研究进展予以综述。 p16 is a newly discovered tumor suppressor gene that plays a regulatory role in the cell cycle during the transition from G1 phase to S phase and competes with cyclinD1 for binding to cyclin dependent protein kinase (CDK) 4 / CDK6 and inhibiting its kinase Activity, prevent cells from entering the S phase from the G1 phase, thereby inhibiting cell proliferation. Studies have shown that it is associated with the occurrence of a variety of tumors, widely present in many tumors in the form of deletion, mutation or methylation, and is involved in the occurrence and development of tumors. The research progress of p16 in oral cancer is reviewed.