论文部分内容阅读
对比进行关本通及其所在的当归四道加吴茱萸生姜汤旧方和八月扎茎及其所在的当归四逆加吴茱萸生姜汤新方短期小鼠肾毒性实验，每日 ｉｇ１次．关木通组 ９ ｇ／ｋｇ、旧方组 ３０ ｇ／ｋｇ、八月扎茎组９ｇ／ｋｇ和新方组３０ｇ／ｋｇ，连续７ｄ。观察小鼠体重和血红蛋白、肾功能及肾组织学变化。结果发现：关木通组及旧方组的体重、尿蛋白和肾组织均明显异常，与阴性对照组比有显著性差异（Ｐ＜０．０５），关木通组病变较重；而八月扎茎组及新方组未见明显异常。提示；关木通及其组成的旧方有相同的肾毒性趋向，而八月扎茎及其组成的新方未见肾毒性反应，因而，当归四边加吴茱萸生姜汤中用木通科八月扎茎可能比用马兜铃科关木通更安全。
Compare Guanbentong and its place of the Angelica Sidaojia Wujingsheng Jiangtang old prescription and the August Zha stem and the Angelica Sini plus Wu Qisheng Jiangtang Xinfang short-term mouse nephrotoxicity experiment, ig1 times a day. Guanmutong group 9 g/kg, old prescription group 30 g/kg, August tie stem group 9 g/kg and Xinfang group 30 g/kg, continuously for 7 days. Observe mouse body weight and hemoglobin, renal function and renal histological changes. The results showed that the body weight, urinary protein, and renal tissue of the Guanmutong group and the old party group were all significantly abnormal, and there was a significant difference compared with the negative control group (P<0.05). The lesions in the Guanmutong group were heavier; There was no obvious abnormality in the new party group. Prompt; Guan Mu Tong and its constituent old party have the same nephrotoxicity trend, but in August the stem and its constituent Xin Fang did not see nephrotoxicity reaction. Therefore, Angelica Sibian plus Wu Kuangsheng ginger decoction in the wood Tsutsui August tie stems It may be safer than using the Aristolochi Section.