论文部分内容阅读
目的:探讨低剂量氨茶碱和呼吸功能训练联合治疗COPD(慢性阻塞性肺疾病)的临床效果。方法:从我院呼吸内科门诊2011年1月-2015年1月收治的COPD患者中按照随机数字表法抽取56例作为研究对象,并根据不同的治疗方法将其分为对照组和观察组,每组各28例。在常规治疗的基础上对照组采用低剂量氨茶碱治疗,观察组采用低剂量氨茶碱联合呼吸功能训练治疗,对比两组患者的治疗效果,治疗前后的肺功能变化和生活质量评分。结果:(1)经对比,观察组治疗的总有效率为92.86%(26/28),显著高于对照组的71.43%(20/28),差异具有统计学意义(P<0.05)。(2)治疗前,两组患者的FEV1、FEV1%、FVC和MWD指标的差异均无统计学意义(P>0.05)。治疗后,4项指标和治疗前比较均显著提升,且观察组的各指标显著高于对照组,差异都具有统计学意义(P<0.05)。(3)治疗前,两组患者的日常生活、社会活动、抑郁程度和焦虑程度的差异均无统计学意义(P>0.05)。治疗后,4项指标和治疗前比较均显著降低,且观察组的各指标显著低于对照组,差异都具有统计学意义(P<0.05)。结论:采用低剂量氨茶碱联合呼吸功能训练治疗COPD具有显著疗效,在提高总有效率的同时还能显著改善患者的肺功能,提高患者的生活质量,值得进行临床推广。
Objective: To investigate the clinical effect of low dose aminophylline and respiratory function training in the treatment of COPD (chronic obstructive pulmonary disease). Methods: Fifty-six patients with COPD who were admitted to our Respiratory Medicine Clinic from January 2011 to January 2015 were randomly divided into control group and observation group according to different treatment methods. Each group of 28 cases. On the basis of routine treatment, the control group was treated with low-dose aminophylline. The observation group was treated with low-dose aminophylline combined with respiratory function training. The treatment effect, the change of lung function and the quality of life before and after treatment were compared between the two groups. Results: (1) By comparison, the total effective rate of the observation group was 92.86% (26/28), which was significantly higher than that of the control group (71.43%, 20/28). The difference was statistically significant (P <0.05). (2) Before treatment, there was no significant difference in FEV1, FEV1%, FVC and MWD between the two groups (P> 0.05). After treatment, the four indexes were significantly increased compared with those before treatment, and the indexes in the observation group were significantly higher than those in the control group (P <0.05). (3) There were no significant differences in daily life, social activities, depression and anxiety between the two groups before treatment (P> 0.05). After treatment, the four indicators were significantly lower than before treatment, and the indicators in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: The low dose of aminophylline combined with respiratory training for the treatment of COPD has a significant effect, while improving the total effective rate can significantly improve patients’ lung function and improve the quality of life of patients, worthy of clinical promotion.